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Gut Microbiome Might Influence Course of Castration-Resistant Prostate Cancer
Castration therapy for prostate cancer often produces an initial clinical response, only to be followed by castration-resistant prostate cancer. An international team of investigators examined whether gut microbes might contribute to castration resistance.
The team studied two strains of mice that are genetically prone to develop prostate cancer and two strains that harbored human prostate cancer cells. As castration resistance developed, two species of gut bacteria that are capable of producing active androgens increased in number. Antibiotic therapy shortly after castration considerably retarded development of castration resistance and reduced tumor volume. Transplantation of feces from mice with castration-resistant prostate cancer or from human castration-resistant prostate cancer patients into other prostate cancer–prone mice at the time of castration caused the mice to rapidly develop castration resistance. Transplantation of feces from human prostate cancer patients who were not castration resistant into these mice delayed development of castration resistance in the mice.
Comment
The gut microbiome already has been shown to influence human tumor initiation and to affect the results of chemotherapy and checkpoint blockade. This study indicates that the lower levels of androgens after castration encourage growth of androgen-producing gut microbes, counteracting the initially positive effects of androgen-deprivation therapy in mice with prostate cancer. Whether antibacterial therapies will help control castration resistance in humans remains to be seen. But this study provides another example of how the gut microbiome is, essentially, a second endocrine system that can affect human physiology.
Citation(s)
Author:
Pernigoni N et al.
Title:
Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis.
Source:
Science
2021
Oct
8; [e-pub].
(Abstract/FREE Full Text)
Empfohlen von
Anthony L. Komaroff, MD